Journal
NEURON
Volume 58, Issue 1, Pages 10-14Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2008.03.015
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Funding
- NIA NIH HHS [R01 AG030207, R37 AG011385, AG011385, R01 AG011385, AG024447, R21 AG024447] Funding Source: Medline
- NINDS NIH HHS [R01 NS041787, NS041787] Funding Source: Medline
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Members of the sirtuin family of protein deacetylases support and promote longevity in diverse organisms and can extend life span when upregulated. Sirtuin pathways also modulate fundamental mechanisms in aging-related neurodegenerative diseases, including protein aggregation, stress responses, mitochondrial homeostasis, and inflammatory processes. In this minireview, we will discuss how progress in understanding the neurobiology of sirtuins is shedding light on the pathogenesis of these devastating conditions. We will also examine the potential and challenges of targeting sirtuin pathways therapeutically.
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