Journal
NEURON
Volume 59, Issue 3, Pages 450-461Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2008.05.015
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Funding
- BBSRC (UK)
- Biotechnology and Biological Sciences Research Council [BB/C003217/1, BB/F003072/1] Funding Source: researchfish
- BBSRC [BB/F003072/1] Funding Source: UKRI
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The ability of vertebrates to detect and avoid damaging extremes of temperature depends on activation of ion channels belonging to the thermo-TRIP family. Injury or inflammation causes the release of inflammatory mediators which lower the threshold for detection of painful levels of heat, a process known as heat hyperalgesia. These inflammatory mediators act by at least three distinct intracellular signaling pathways. Here, we show that modulation of the sensitivity of the heat-activated ion channel TRPV1 by the protein kinases PKA and PKC and by the phosphatase calcineurin depends on the formation of a signaling complex between these enzymes, the scaffolding protein AKAP79/150 and TRPV1. We identify a critical region in the TRPV1 C-terminal which mediates binding of AKAP79/150. If binding is prevented, then sensitization by both bradykinin and PGE(2) is abrogated. AKAP79/150 is therefore a final common element in heat hyperalgesia, on which the effects of multiple proinflammatory mediators converge.
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