Journal
NEURON
Volume 57, Issue 1, Pages 121-134Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2007.11.023
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The physiological conditions under which adenosine A(2A) receptors modulate synaptic transmission are presently unclear. We show that A(2A) receptors are localized postsynaptically at synapses between mossy fibers and CA3 pyramidal cells and are essential for a form of long-term potentiation (LTP) of NMDA-EPSCs induced by short bursts of mossy fiber stimulation. This LTP spares AMPA-EPSCs and is likely induced and expressed postsynaptically. It depends on a postsynaptic Ca2+ rise, on G protein activation, and on Src kinase. In addition to A(2A) receptors, LTP of NMDA-EPSCs requires the activation of NMDA and mGluR5 receptors as potential sources of Ca2+ increase. LTP of NMDA-EPSCs displays a lower threshold for induction as compared with the conventional presynaptic mossy fiber LTP; however, the two forms of LTP can combine with stronger induction protocols. Thus, postsynaptic A(2A) receptors may potentially affect information processing in CA3 neuronal networks and memory performance.
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