Journal
NEURON
Volume 59, Issue 6, Pages 972-985Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2008.07.037
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Funding
- NIH [NS28182]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Naito Foundation
- Mitsubishi Foundation
- Research Abroad of the Japan Society
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In Drosophila embryos and larvae, a small number of identified motor neurons innervate body wall muscles in a highly stereotyped pattern. Although genetic screens have identified many proteins that are required for axon guidance and synaptogenesis in this system, little is known about the mechanisms by which muscle fibers are defined as targets for specific motor axons. To identify potential target labels, we screened 410 genes encoding cell-surface and secreted proteins, searching for those whose overexpression on all muscle fibers causes motor axons to make targeting errors. Thirty such genes were identified, and a number of these were members of a large gene family encoding proteins whose extracellular domains contain leucine-rich repeat (LRR) sequences, which are protein interaction modules. By manipulating gene expression in muscle 12, we showed that four LRR proteins participate in the selection of this muscle as the appropriate synaptic target for the RP5 motor neuron.
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