Journal
NEURON
Volume 57, Issue 2, Pages 303-313Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2007.11.035
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Funding
- NIMH NIH HHS [P50 MH077970, MH077970, R01 MH080283, R01 MH080283-01, MH080283, MH059733, P50 MH077970-02, R01 MH059733-06, R01 MH059733] Funding Source: Medline
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The acquisition of new memories for places and events requires synaptic plasticity in the hippocampus, and plasticity depends on temporal coordination among neurons. Spatial activity in the hippocampus is relatively disorganized during the initial exploration of a novel environment, however, and it is unclear how neural activity during the initial stages of learning drives synaptic plasticity. Here we show that pairs of CA1 cells that represent overlapping novel locations are initially more coactive and more precisely coordinated than are cells representing overlapping familiar locations. This increased coordination occurrs specifically during brief, high-frequency events (HFEs) in the local field potential that are similar to ripples and is not associated with better coordination of place-specific neural activity outside of HFEs. As novel locations become more familiar, correlations between cell pairs decrease. Thus, hippocampal neural activity during learning has a unique structure that is well suited to induce synaptic plasticity and to allow for rapid storage of new memories.
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