Journal
NEURON
Volume 59, Issue 1, Pages 8-10Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2008.06.014
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Funding
- NINDS NIH HHS [R01 NS046006-05] Funding Source: Medline
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In this month's issue of Nature Medicine, Town et al. suggest that peripheral macrophages invading the brain reduce cerebral amyloidosis and thus may play a key role in the pathogenesis of Alzheimer's disease (AD). This observation intensifies the longstanding controversy of whether mononuclear cells such as macrophages and/or microglial cells are beneficial or detrimental in AD.
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