Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 141, Issue -, Pages 135-143Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2015.01.039
Keywords
Hydroxyapatite; Nanoparticles; Green route; Opuntia ficus indica; Bioactivity; Simulated body fluid
Categories
Funding
- Council of Scientific and Industrial Research (CSIR - India) [01(2547)/11/EMR-II]
- Department of Science and Technology (DST - India) [DST/TSG/NTS/2011/73, SB/EMEQ-185/2013]
- University Grants Commission, New Delhi, India (UGC) [F. 30-1/2013(SA-II)/RA-2012-14-NEW-SC-TAM-3240, F. 30-1/2013(SA-II)/RA-2012-14-NEW-GE-TAM-3228]
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In the present study, we have adapted a facile and efficient green route for the synthesis of HAP nanopartides using pectin as a template which was extracted from the peel of prickly pear (Opuntia ficus indica) fruits. The concentration of pectin plays a major role in the behavior of crystallinity, purity, morphology as well as biological property of the as-synthesized HAP nanoparticles. The extracted pectin and the as-synthesized nanoparticles were characterized by various analytical techniques. The in vitro apatite formation on the surface of the as-synthesized nanoparticles in simulated body fluid (SBF) for various days showed an enhanced bioactivity. Also, the antimicrobial activity was investigated using various microorganisms. All the results revealed the formation of pure, low crystalline and discrete granular like HAP nanoparticles of size around 25 nm with enhanced biological and antimicrobial activities. Hence the as-synthesized nanoparticles can act as a better bone regenerating material in the field of biomedicine. (C) 2015 Elsevier B.V. All rights reserved.
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