Journal
NEUROMOLECULAR MEDICINE
Volume 10, Issue 1, Pages 40-45Publisher
HUMANA PRESS INC
DOI: 10.1007/s12017-008-8023-4
Keywords
DJ-1; LTD; LTP; Parkinson's disease; dopamine receptor; hippocampal CA1
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Funding
- NATIONAL INSTITUTE ON AGING [ZIAAG000942, Z01AG000945, ZIAAG000945, Z01AG000942, Z01AG000959, ZIAAG000959] Funding Source: NIH RePORTER
- Intramural NIH HHS Funding Source: Medline
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Mutations in DJ-1 cause inherited Parkinson's disease (PD) in several families. The normal function of DJ-1 is unknown, but mice lacking DJ-1 exhibit a deficit in dopaminergic signaling in the striatum. Since the hippocampus contains relatively high levels of DJ-1, and PD patients are often cognitively impaired, we evaluated the effects of DJ-1 deficiency on the plasticity of hippocampal CA1 synapses. LTP was slightly impaired and LTD was abolished in DJ-1-/- mice, whereas DJ-1+/- mice exhibited no alterations in synaptic plasticity. The dopamine receptor D2/3 agonist quinpirole rescued LTD in DJ-1-/- mice, suggesting a role for impaired dopaminergic signaling in the hippocampal LTD deficit.
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