Journal
NEUROLOGY
Volume 82, Issue 10, Pages 858-864Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000000204
Keywords
-
Categories
Funding
- Michael J. Fox Foundation for Parkinson's Research
- National Institute of Neurological Disorders and Stroke [U24 NS072026]
- Grants-in-Aid for Scientific Research [24500429] Funding Source: KAKEN
Ask authors/readers for more resources
Objective:This study investigates salivary gland biopsies in living patients with Parkinson disease (PD).Methods:Patients with PD for 5 years underwent outpatient transcutaneous needle core biopsies (18-gauge or 16-gauge) of 1 submandibular gland. Minor salivary glands were removed via a small incision in the lower lip. Tissue was fixed in formalin and serial 6-mu m paraffin sections were immunohistochemically stained for phosphorylated -synuclein and reviewed for evidence of Lewy type -synucleinopathy (LTS).Results:Fifteen patients with PD were biopsied: 9 female/6 male, mean age 68.7 years, mean PD duration 11.8 years. Twelve of the needle core biopsies had microscopically evident submandibular gland tissue to assess and 9/12 (75%) had LTS. Only 1/15 (6.7%) minor salivary gland biopsies were positive for LTS. Five patients had an adverse event; all were minor and transient.Conclusions:This study demonstrates the feasibility of performing needle core biopsies of the submandibular gland in living patients with PD to assess LTS. Although this was a small study, this tissue biopsy method may be important for tissue confirmation of PD in patients being considered for invasive procedures and in research studies of other PD biomarkers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available