Journal
NEUROLOGY
Volume 83, Issue 15, Pages 1345-1352Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000000867
Keywords
-
Categories
Funding
- University of Western Australia
- Freemasons' Western Australia Student Award
- CSIRO
- Science and Industry Endowment Fund
- National Health and Medical Research Council via Dementia Collaborative Research Centres program
- Pfizer International
- McCusker Alzheimer's Research Foundation Inc.
- Cooperative Research Centre for Mental Health from Australian Government
Ask authors/readers for more resources
Objective: To investigate the association between habitual physical activity levels and brain temporal lobe volumes, and the interaction with the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. Methods: This study is a cross-sectional analysis of 114 cognitively healthy men and women aged 60 years and older. Brain volumes quantified by MRI were correlated with self-reported physical activity levels. The effect of the interaction between physical activity and the BDNF Val66Met polymorphism on brain structure volumes was assessed. Post hoc analyses were completed to evaluate the influence of the APOE epsilon 4 allele on any found associations. Results: The BDNF Val66Met polymorphism interacted with physical activity to be associated with hippocampal (beta = -0.22, p = 0.02) and temporal lobe (beta = -0.28, p = 0.003) volumes. In Val/Val homozygotes, higher levels of physical activity were associated with larger hippocampal and temporal lobe volumes, whereas in Met carriers, higher levels of physical activity were associated with smaller temporal lobe volume. Conclusion: The findings from this study support higher physical activity levels in the potential attenuation of age-and disease-related hippocampal and temporal lobe volume loss in Val/Val homozygotes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available