Journal
NEUROLOGY
Volume 79, Issue 24, Pages 2321-2327Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0b013e318278b607
Keywords
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Funding
- National Institute on Aging [R01 AG11101, R01 AG10161, R01 AG22018]
- National Heart, Lung and Blood Institute [R01 HL084209]
- National Institute of Environmental Health Sciences grant [R01 ES10902]
- NIH [AG022018, AG031553, AG024871, AG15819, AG026395, AG017917, AG009966, AG034374, AG39478, AG036547, AG11101, AG036650, AG09966, AG030146, AG10161, AG021972, ES10902, NR009543, HL084209, AG125051, AG032247, AG033172, AG027708]
- Alzheimer's Association [NIRGD-11-205469]
- [AG040738]
- [HL091290]
- [HD068045]
- [MD003422]
- [HL089862]
- [HD042849]
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Objectives: Early-life adversity is related to adult health in old age but little is known about its relation with cognitive decline. Methods: Participants included more than 6,100 older residents (mean age = 74.9 [7.1] years; 61.8% African American) enrolled in the Chicago Health and Aging Project, a geographically defined, population-based study of risk factors for Alzheimer disease. Participants were interviewed at approximately 3-year intervals for up to 16 years. The interview included a baseline evaluation of early-life adversity, and administration of 4 brief cognitive function tests to assess change in cognitive function. We estimated the relation of early-life adversity to rate of cognitive decline in a series of mixed-effects models. Results: In models stratified by race, and adjusted for age and sex, early-life adversity was differentially related to decline in African Americans and whites. Whereas no measure of early-life adversity related to cognitive decline in whites, both food deprivation and being thinner than average in early life were associated with a slower rate of cognitive decline in African Americans. The relations were not mediated by years of education and persisted after adjustment for cardiovascular factors. Conclusions: Markers of early-life adversity had an unexpected protective effect on cognitive decline in African Americans. Neurology (R) 2012;79:2321-2327
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