Journal
NEUROLOGY
Volume 78, Issue 4, Pages 241-249Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0b013e3182436598
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Funding
- NIH/NCCAM [AT004777]
- NIH/NIA [P30 AG008017]
- NIH/NCRR, Oregon Clinical and Translational Research Institute [UL1 RR024140]
- Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development
- NIH [P01 AT002034, T32 AT002688]
- NIH/NIA
- USDA National Institute for Food and Agriculture
- USANA Health Sciences, Inc., Salt Lake City, UT
- Department of Veterans Affairs
- Elan Corporation
- Intel Corporation
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Objective: To examine the cross-sectional relationship between nutrient status and psychometric and imaging indices of brain health in dementia-free elders. Methods: Thirty plasma biomarkers of diet were assayed in the Oregon Brain Aging Study cohort (n = 104). Principal component analysis constructed nutrient biomarker patterns (NBPs) and regression models assessed the relationship of these with cognitive and MRI outcomes. Results: Mean age was 87 +/- 10 years and 62% of subjects were female. Two NBPs associated with more favorable cognitive and MRI measures: one high in plasma vitamins B (B1, B2, B6, folate, and B12), C, D, and E, and another high in plasma marine omega-3 fatty acids. A third pattern characterized by high trans fat was associated with less favorable cognitive function and less total cerebral brain volume. Depression attenuated the relationship between the marine omega-3 pattern and white matter hyperintensity volume. Conclusion: Distinct nutrient biomarker patterns detected in plasma are interpretable and account for a significant degree of variance in both cognitive function and brain volume. Objective and multivariate approaches to the study of nutrition in brain health warrant further study. These findings should be confirmed in a separate population. Neurology (R) 2012; 78: 241-249
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