Journal
NEUROLOGY
Volume 73, Issue 22, Pages 1914-1922Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0b013e3181c47cc2
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Funding
- EMD Serono, Inc.
- NIH/NEI [R03EY014573]
- National Multiple Sclerosis Society
- Karolinska Institutet
- Torsten and Ragnar Soderberg Foundation
- Harvard Foundation
- Swedish Medical Research Council
- Sanofi-aventis
- Merck Serono
- Novartis
- Teva Pharmaceutical Industries Ltd.
- Italian Ministry of Health
- Italian Ministry of Research and Education
- Italian Foundation for Multiple Sclerosis
- Schering-Plough Corp.
- Biogen Idec
- Leeds Teaching Hospitals Special trustees
- Bayer Schering Pharma
- Catholic University of Louvain
- University of Ulm
- NATIONAL EYE INSTITUTE [R03EY014573] Funding Source: NIH RePORTER
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There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in CSF are being used in clinical practice. One of the most critical factors in CSF biomarker research is the inadequate powering of studies because of the lack of sufficient samples that can be obtained in single-center studies. Therefore, collaboration between investigators is needed to establish large biobanks of well-defined samples. Standardized protocols for biobanking are a prerequisite to ensure that the statistical power gained by increasing the numbers of CSF samples is not compromised by preanalytical factors. Here, a consensus report on recommendations for CSF collection and biobanking is presented, formed by the BioMS-eu network for CSF biomarker research in multiple sclerosis. We focus on CSF collection procedures, preanalytical factors, and high-quality clinical and paraclinical information. The biobanking protocols are applicable for CSF biobanks for research targeting any neurologic disease. Neurology (R) 2009; 73: 1914-1922
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