Journal
NEUROLOGIST
Volume 16, Issue 6, Pages 375-378Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/NRL.0b013e3181b126e3
Keywords
autologous peripheral hematopoietic stem cell transplantation; neuromyelitis optics; therapy
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Funding
- Sun Yat-Sen University [2007027]
- Science and technology Project of Guangzhou [2060402]
- Science and technology Project of Guangdong Province [2006B36004003]
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Autologous peripheral hematopoietic stem cell transplantation (APHSCT) was performed to treat a patient with neuromyelitis optica. We observed that the patient achieved clinical remission after APHSCT during 12 months of follow-up. The patient improved on the expanded disability status scale neurologic assessment and the Scripps neurologic rating scale worksheet scores on follow-up examination compared with baseline. The MRI abnormalities on T1WI and T2WI improved. The postpartum maternal blood helper T (CD3(+)CD4(+) T cell) and the CD4(+)/CD8(+) ratio were decreased, and the cytotoxic T (CD3(+)CD8(+) T) cell increased. This shows that APHSCT in this patient with neuromyelitis optica appears to reduce the frequency of attacks with improvement in disability. However, a larger study with more patients and a longer follow-up would be required to assess the encouraging preliminary results.
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