Journal
NEUROLOGIST
Volume 16, Issue 3, Pages 199-202Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/NRL.0b013e3181a3cb53
Keywords
toxic vasculopathy; cerebral vasculopathy; 2C-B phenethylamine; designer drug
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Background: 4-bromo-2,5-dimethoxyphenethylamine (2C-B) is a designerdrug variant of 3,4-methylenedioxymethamphetamine (ecstasy) whose recreational use has increased significantly over the last 10 years. Neurologic consequences of 2C-B usage are currently unknown. Case Report: A 43-year-old woman experienced severe headaches within 48 hours of taking liquid 2C-B, after which time she developed progressive encephalopathy and quadraparesis, which did not improve over several months. MRA and cerebral angiogram imaging demonstrated profound vascular abnormalities of large, medium, and small-caliber vessels with subsequent watershed infarction. Brain biopsy and cerebrospinal fluid studies ruled out an inflammatory process. Conclusions: This case demonstrates an idiosyncratic and devastating neurologic response to 2C-B, a recreational drug whose popularity has increased with widespread availability of online guides for its synthesis.
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