Journal
NEUROLOGICAL SCIENCES
Volume 35, Issue 6, Pages 815-821Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-013-1603-6
Keywords
Vincristine; Neuropathic pain; Matrine; Antinociceptive
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Funding
- National Natural Science Foundation of China [81360182, 81160524]
- International Cooperation of Ningxia Scientific Research Projects
- Ningxia Health Department [20130X]
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Chemotherapy drugs treatment causes neuropathic pain, hyperalgesia and allodynia are common components of neuropathic pain, so effectively therapeutic strategy is required. In this study, we evaluated the antinociceptive effects of matrine on vincristine-induced neuropathic pain in mice. Vincristine (100 mu g/kg i.p.) was administered once per day for 7 days (day 0-6) in mice. Matrine (15, 30, 60 mg/kg, i.p.) was repeated administration in early phase (day 0-6) or late phase (day 7-13). Hyperalgesia and allodynia were evaluated by withdrawal response using von Frey filaments, plantar and cold-plate on 7, 14 and 21 day. Injection of vincristine produced mechanical hyperalgesia and cold allodynia. Matrine was found to produce a protective role in both von Frey filaments and cold-plate test. The analysis of the effect supports the hypothesis that matrine is useful in therapy of vincristine-induced neuropathic pain. In conclusion, this study demonstrates that administration of matrine is associated with antinociceptive effect on mechanical and cold stimuli in a mice model of vincristine-induced neuropathy pain.
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