Journal
NEUROLOGICAL SCIENCES
Volume 33, Issue 2, Pages 261-267Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-011-0672-7
Keywords
Blepharospasm; Hemifacial spasm; Botulinum toxin; Botox; Dysport; Dose equivalence ratio
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Botox (R) and Dysport (R) are the preparations of botulinum neurotoxin most widely used for therapeutic purposes. Several studies have addressed the topic of the equivalency ratio (D/B ratio) to be used in clinical practice and whether a reliable value exists is still a matter of debate. To this purpose, we ideated a novel paradigm by retrospectively examining the patients affected by hemifacial spasm and blepharospasm. We compared the pairs of treatments with a switch from one brand to the other undergone by the same patient in consecutive sessions with overlapping clinical outcome. Out of 2006 treatments, we found 51 treatment pairs. D/B ratio was extremely variable (range 1.2-13.3) and in most cases (65%) it was between 1:3 and 1:5. In conclusion, even if the 1:4 ratio might be reliable for clinical purpose, a true bioequivalence between Dysport (R) and Botox (R) might not exist due to the intrinsic difference in their pharmacokinetic properties.
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