Journal
NEUROLOGICAL SCIENCES
Volume 33, Issue 4, Pages 825-829Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-011-0837-4
Keywords
Amyotrophic lateral sclerosis; Apoptosis; Caspase-9; Neurodegeneration; Pathomechanisms; Serum
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It is known that apoptosis may play a role in the pathophysiology of amyotrophic lateral sclerosis (ALS). Moreover, caspase-9 is implicated in the apoptosis pathway. The aim of the study was to investigate caspase-9 levels in serum of patients with ALS. The study involved 30 patients with ALS and 30 patients from the control group. The serum caspase-9 levels were measured using the enzyme-linked immunosorbent method. The study showed that caspase-9 levels are significantly increased in serum of the patients with ALS comparing to the control group (p < 0.05). There was a significant correlation of serum caspase-9 levels with severity of clinical state of ALS patients and duration of the disease (p < 0.05). The results indicate that caspase-9 may be implicated in pathomechanism of neurodegeneration in ALS.
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