Journal
NEUROLOGICAL RESEARCH
Volume 36, Issue 12, Pages 1094-1098Publisher
MANEY PUBLISHING
DOI: 10.1179/1743132814Y.0000000434
Keywords
MRI; JJVCPE; Aquaporin; Virchow-Robin space; Interstitial flow
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Funding
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [25461310] Funding Source: KAKEN
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Recent studies on cerebrospinal fluid (CSF) homeostasis emphasize the importance of water influx into the peri-capillary (Virchow-Robin) space through aquaporin 4 (AQP-4). This water flow is believed to have the functionality equivalent to the systemic lymphatic system and plays a critical role in beta-amyloid clearance. Using a newly developed molecular imaging technique capable of tracing water molecules, in vivo, water influx into the CSF was quantitatively analyzed in senile plaque (SP) bearing transgenic Alzheimer's disease (AD) model mice. The results unequivocally demonstrated that water influx into CSF is significantly impaired in SP-bearing transgenic mice, the degree of which being virtually identical to that previously observed in AQP-4 knockout mice. The study strongly indicates that disturbance in AQP-4-based water flow and, hence, impairment in beta-amyloid clearance play a significant role in SP formation.
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