Journal
NEUROLOGICAL RESEARCH
Volume 35, Issue 9, Pages 903-911Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1179/1743132813Y.0000000233
Keywords
Demyelination; Experimental autoimmune encephalomyelitis (EAE); Multiple sclerosis (MS); Optic nerve
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Funding
- GEMACBIO (St Jean d'Illac, France)
- Institut pour le Developpement de la Recherche en Pathologie Humaine et Therapeutique (IDRPHT) (Talence, France)
- Red de Terapia Celular de Castilla y Leon (Spain)
- Consejeria de Educacion de la Junta de Castilla y Leon (Spain) [SA099A08]
- INCYL-Federacion de Cajas de Ahorro de Castilla y Leon (Spain)
- Ministerio de Educacion y Ciencia (Spain) [SA F2007-62060]
- Grupos Consolidados del Gobierno Vasco
- RETICS Red Patologia Ocular [RD07/0062, BIOEF08/ER/006]
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Objectives: Chronic experimental autoimmune encephalomyelitis (EAE) was induced in rats to evaluate the potential protective effect of GEMSP, a mixture made up of fatty acids (FA), vitamins, and amino acids or their derivatives, linked to Poly-L-Lysine, on the myelin sheath of the optic nerve. Methods: To evaluate the effects of GEMSP on the optic nerve, animals were divided into three experimental groups: (1) EAE rats treated with GEMSP; (2) EAE rats treated with 0.9% NaCl; and (3) control, non-EAE rats. Using electron microscopy, we investigated the possibility that this new drug candidate has a myelin-protective role. Results: A marginally significant reduction in the thickness of the myelin around optic nerve medium-size axons (diameter between 0.8-1.3 mu m) was found in EAE rats. Treatment of EAE rats with GEMSP ameliorated myelin damage. Significantly increased myelin thickness was found when animals in groups 2 and 3 were compared. However, the number of myelinated axons studied was not altered in groups 1 or 2 when compared to controls. Discussion: Our results suggest that in a model of demyelination, GEMSP protects and enhances the formation of the myelin sheath of the optic nerve and therefore could be a potential drug candidate to reduce optic nerve pathogenesis in multiple sclerosis (MS).
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