Journal
NEUROLOGIC CLINICS
Volume 32, Issue 3, Pages 647-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ncl.2014.04.009
Keywords
Toxic myopathies; Muscle tissue; Statins; Myopathy
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Funding
- Institutional Clinical and Translational Science Award, NIH/National Center for Advancing Translational Sciences [UL1TR000001]
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Muscle tissue is highly sensitive to many substances. Early recognition of toxic myopathies is important, because they potentially are reversible on removal of the offending drug or toxin, with greater likelihood of complete resolution the sooner this is achieved. Clinical features range from mild muscle pain and cramps to severe weakness with rhabdomyolysis, renal failure, and even death. The pathogenic bases can be multifactorial. This article reviews some of the common toxic myopathies and their clinical presentation, histopathologic features, and possible underlying cellular mechanisms.
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