Journal
NEUROLOGIC CLINICS
Volume 31, Issue 1, Pages 219-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ncl.2012.09.014
Keywords
Motor neuron diseases; Amyotrophic lateral sclerosis; Spinal cord; Familial amyotrophic lateral sclerosis
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Spinal cord motor neuron diseases affect lower motor neurons in the ventral horn. This article focuses on the most common spinal cord motor neuron disease, amyotrophic lateral sclerosis, which also affects upper motor neurons. Also discussed are other motor neuron diseases that only affect the lower motor neurons. Despite the identification of several genes associated with familial amyotrophic lateral sclerosis, the pathogenesis of this complex disease remains elusive.
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