Journal
NEUROLOGIC CLINICS
Volume 29, Issue 2, Pages 293-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ncl.2011.01.006
Keywords
Multiple sclerosis; Prognosis; Prognostic factors; Disability; Epidemiology
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Funding
- Multiple Sclerosis Society of Canada
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Several prognostic factors of long-term irreversible disability, mainly demographic and clinical, have been described in multiple sclerosis (MS). Most predictors have a minor influence on the long-term prognosis, and efforts are currently shifting toward finding relevant paraclinical predictors. By contrast, the study of prognostic factors has given some insights into the pathogenesis of MS, notably regarding the relation between relapses and long-term disability, and has emphasized the need to elucidate the exact mechanisms underlying neurodegeneration for the development of new therapeutic targets.
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