Journal
NEUROIMMUNOMODULATION
Volume 15, Issue 4-6, Pages 251-259Publisher
KARGER
DOI: 10.1159/000156468
Keywords
Chronic Stress; Immune Dysregulation; Aging; Vaccine; Herpesviruses; Interleukin-6; Inflammation; Telomeres; Psychoneuroimmunology
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Funding
- Fonds de la Recherche en Sante du Quebec Doctoral Training Award
- Ohio State University Graduate Fellowship
- NIH [R01 CA0126857, RO1 AG029562, R21 AG025732]
- General Clinical Research Center [MO1-RR0034]
- Comprehensive Cancer Center [CA16058]
- NATIONAL CANCER INSTITUTE [P30CA016058, R01CA126857] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR025755, M01RR000034] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R21AG025732, R01AG029562] Funding Source: NIH RePORTER
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Aging is associated with a natural dysregulation in immune functioning which may be amplified when it occurs in the context of chronic stress. Family dementia caregiving provides an excellent model to study the impact of chronic stress on immune functioning among older individuals. Empirical data suggest that the stress of caregiving dysregulates multiple components of innate and adaptive immunity. Elderly caregivers have poorer responses to vaccines, impaired control of latent viruses, exaggerated production of inflammatory mediators and accelerated cellular aging, compared to noncaregiving older adults. The chronic stress-induced immune dysregulation observed among older caregivers appears to be of sufficient magnitude to impact health. Furthermore, evidence suggests that chronic stress leads to premature aging of the immune system. Copyright (C) 2008 S. Karger AG, Basel
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