Journal
NEUROIMMUNOMODULATION
Volume 15, Issue 3, Pages 170-175Publisher
KARGER
DOI: 10.1159/000153421
Keywords
Serotonin; Plasticity; Brain development; Critical period; Nutrition; Tryptophan
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Funding
- Brazilian National Research Council (CNPq)
- Research Foundation of the State of Rio de Janeiro (FAPERJ)
- CAPES
- PAPES/FIOCRUZ
- PRONEX/MCT
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Tryptophan is an essential amino acid and metabolic precursor of serotonin. Serotonin is both a classical neurotransmitter and a signaling molecule that plays crucial roles in the development of neural circuits and plasticity. The specification of neural circuits in rodents occurs during the postnatal period with conspicuous influence of environmental factors including the nutritional status. Sensory, motor and cognitive systems develop during a critical period, a time window that is crucial to the use-dependent organization of neuronal circuits. This review presents recent experimental findings that disclose some mechanism of tryptophan- and serotonin-dependent plasticity in the developing and adult brain. Copyright (c) 2008 S. Karger AG, Basel
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