Central Nervous System Tuberculosis Pathophysiology and Imaging Findings

Central Nervous System Tuberculosis: Pathophysiology and Imaging Findings Deepak Patkar, Jayant Narang, Rama Yanamandala, Malini Lawande, and Gaurang V. Shah With the onset of the human immunodeficiency virus pandemic, the incidence of tuberculosis, including central nervous system (CNS) tuberculosis, has increased in developed countries. It is no longer a disease confined to underdeveloped and developing countries. The imaging appearance has become more complex with the onset of multidrug-resistant tuberculosis. Imaging plays an important role in the early diagnosis of CNS tuberculosis and may prevent unnecessary morbidity and mortality. This article presents an extensive review of typical and atypical imaging appearances of intracranial tuberculosis, and discusses pathogenesis, patterns of involvement, and advances in imaging of intracranial tuberculosis.