Journal
NEUROIMAGE
Volume 98, Issue -, Pages 23-30Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2014.04.081
Keywords
Apolipoprotein E; Resting-state MRI; Diffusion tensor imaging; Hippocampus; Gender; Alzheimer's disease
Funding
- Alzheimer's Research UK studentship [1077089]
- Rhodes scholarship
- University of Oxford Clarendon scholarship
- HDH Wills 1965 charitable trusts [1117747]
- National Institute for Health Research (NIHR), UK as part of the Oxford Biomedical Research Centre (BRC)
- Gordon Edward Small's Charitable Trust [SC008962]
- Oxford BRC
- MRC [G1001354] Funding Source: UKRI
- Alzheimers Research UK [ARUK-PPG2012A-5, ART-PhD2010-4] Funding Source: researchfish
- Medical Research Council [G1001354, MR/K013351/1] Funding Source: researchfish
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Important risk factors for Alzheimer's disease (AD) are ageing and the Apolipoprotein E (APOE) epsilon 4 allele, with female APOE epsilon 4 carriers having the greatest risk. In this study we investigated effects of AD risk factors on connectivity of the hippocampus, a structure that shows early AD related pathology. Resting-state functional magnetic resonance imaging and diffusion tensor imaging data from 86 cognitively healthy subjects aged 30 to 78 years were analysed. Female APOE epsilon 4 carriers showed overall significantly reduced functional connectivity between the hippocampus and precuneus/posterior cingulate cortex (PCC) and a significant age-related decrease in connectivity of these regions. In females and APOE epsilon 4 carriers we found significantly reduced white matter integrity of the tract connecting the hippocampus and PCC with a significant positive correlation of white matter integrity and resting-state connectivity. Increased vulnerability of the connection between the hippocampus and PCC might be one reason for increased AD risk in female APOE epsilon 4 carriers. Interventions targeting hippocampal connectivity might be especially effective in this at risk population. (C) 2014 Elsevier Inc. All rights reserved.
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