Journal
NEUROIMAGE
Volume 85, Issue -, Pages 51-63Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2013.06.017
Keywords
Diffuse correlation spectroscopy; Cerebral blood flow; Functional neuroimaging; Diffuse optics; Near-infrared spectroscopy; Cerebral metabolic rate of oxygen extraction; Ischemic stroke; Neurocritical care; Neonatology
Funding
- National Institute of Health [RR002305, EB015893, R01-NS060653, HL077699]
- Fundacio Cellex Barcelona, Marie Curie IRG
- Institute de Salud Carlos III (DOMMON, FIS)
- Ministerio de Economia y Comepetitividad, Institucio CERCA (DOCNEURO) [PROVAT-002-11]
- Generalitat de Catalunya, European Regional Development Fund (FEDER/ERDF)
- LASERLAB
- Photonics4Life consortia
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Diffuse correlation spectroscopy (DCS) uses the temporal fluctuations of near-infrared (NIR) light to measure cerebral blood flow (CBF) non-invasively. Here, we provide a brief history of DCS applications in the brain with an emphasis on the underlying physical ideas, common instrumentation and validation. Then we describe recent clinical research that employs DCS-measured CBF as a biomarker of patient well-being, and as an indicator of hemodynamic and metabolic responses to functional stimuli. (C) 2013 Elsevier Inc. All rights reserved.
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