Journal
NEUROIMAGE
Volume 81, Issue -, Pages 381-392Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2013.05.046
Keywords
Anti-correlation; Attention; Connectivity-based parcellation; Social cognition; Temporo-parietal junction
Funding
- Human Brain Project [R01-MH074457-01A1]
- Helmholtz Initiative on Systems-Biology The Human Brain Model
- German National Academic Foundation
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The right temporo-parietal junction (RTPJ) is consistently implicated in two cognitive domains, attention and social cognitions. We conducted multi-modal connectivity-based parcellation to investigate potentially separate functional modules within RTPJ implementing this cognitive dualism. Both task-constrained meta-analytic coactivation mapping and task-free resting-state connectivity analysis independently identified two distinct clusters within RTPJ, subsequently characterized by network mapping and functional forward/reverse inference. Coactivation mapping and resting-state correlations revealed that the anterior cluster increased neural activity concomitantly with a midcingulate-motor-insular network, functionally associated with attention, and decreased neural activity concomitantly with a parietal network, functionally associated with social cognition and memory retrieval. The posterior cluster showed the exact opposite association pattern. Our data thus suggest that RTPJ links two antagonistic brain networks processing external versus internal information. (C) 2013 Elsevier Inc. All rights reserved.
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