Journal
NEUROIMAGE
Volume 80, Issue -, Pages 426-444Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2013.04.087
Keywords
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Funding
- Australian National Health and Medical Research Council [1050504]
- University of Melbourne
- Monash University
- Australian Research Council
- National Health and Medical Research Council
- Brain Network Recovery Group [JSMF22002082]
- Melbourne Neuroscience Institute
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The human brain is a complex, interconnected network par excellence. Accurate and informative mapping of this human connectome has become a central goal of neuroscience. At the heart of this endeavor is the notion that brain connectivity can be abstracted to a graph of nodes, representing neural elements (e.g., neurons, brain regions), linked by edges, representing some measure of structural, functional or causal interaction between nodes. Such a representation brings connectomic data into the realm of graph theory, affording a rich repertoire of mathematical tools and concepts that can be used to characterize diverse anatomical and dynamical properties of brain networks. Although this approach has tremendous potential - and has seen rapid uptake in the neuroimaging community - it also has a number of pitfalls and unresolved challenges which can, if not approached with due caution, undermine the explanatory potential of the endeavor. We review these pitfalls, the prevailing solutions to overcome them, and the challenges at the forefront of the field. (C) 2013 Elsevier Inc. All rights reserved.
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