Journal
NEUROIMAGE
Volume 80, Issue -, Pages 330-338Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2013.03.059
Keywords
Biophysical model; Networks; Connectivity; Connectome; Bayes; DCM; Generative embedding; Bottom-up model; MEG; EEG; FMRI; Diffusion; Multi-modal
Funding
- Wellcome Trust
- National Institute for Health Research (NIHR) Oxford Biomedical Research Centre based at Oxford University Hospitals Trust Oxford University
- Rene and Susanne Braginsky Foundation
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A core goal of human connectomics is to characterise the neural pathways that underlie brain function. This can be largely achieved noninvasively by inferring white matter connectivity using diffusion MRI data. However, there are challenges. First, diffusion tractography is blind to directed connections, or whether a connection is expressed functionally. Second, we need to be able to go beyond the characterization of anatomical pathways, to understand distributed brain function that results from them. In particular, we need to characterise effective connectivity using functional imaging modalities, such as FMRI and M/EEG, to understand its context-sensitivity (e.g., modulation by task), and how it changes with synaptic plasticity. Here, we consider the critical role that biophysical network models have to play in meeting these challenges, by providing a principled way to conciliate information from anatomical and functional data. They also provide biophysically meaningful parameters, through which we can better understand brain function. In a translational setting, well-validated models may shed light on the mechanisms of individual disease processes. (C) 2013 Elsevier Inc. All rights reserved.
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