Journal
NEUROIMAGE
Volume 59, Issue 4, Pages 3967-3975Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2011.10.076
Keywords
T-2* decay; R-2* relaxation; Phase image; Resonance frequency image; Demyelination; Cuprizone; Formalin fixation
Funding
- NIH, NINDS
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T-2*-weighted gradient-echo MRI images at high field (>= 7 T) have shown rich image contrast within and between brain regions. The source for these contrast variations has been primarily attributed to tissue magnetic susceptibility differences. In this study, the contribution of myelin to both T-2* and frequency contrasts is investigated using a mouse model of demyelination based on a cuprizone diet. The demyelinated brains showed significantly increased T-2* in white matter and a substantial reduction in gray-white matter frequency contrast, suggesting that myelin is a primary source for these contrasts. Comparison of in-vivo and in-vitro data showed that, although tissue T-2* values were reduced by formalin fixation, gray-white matter frequency contrast was relatively unaffected and fixation had a negligible effect on cuprizone-induced changes in T-2* and frequency contrasts. Published by Elsevier Inc.
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