Journal
NEUROIMAGE
Volume 60, Issue 2, Pages 871-878Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2012.01.102
Keywords
Walking speed; Volumetric MRI; Gait; Basal ganglia; Caudate nucleus; Aging
Funding
- Fondation pour la Recherche Medicale
- Caisse Nationale Maladie des Travailleurs Salaries
- Direction Generale de la Sante
- Institut National de Prevention et d'Education pour la Sante (INPES)
- Conseils Regionaux of Bourgogne
- Fondation de France
- Ministry of Research-INSERM
- Mutuelle Generale de l'Education Nationale
- Institut de la Longevite
- Conseil General de la Cote d'or
- Haute Autorite de la Sante
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Cerebral white matter lesions are associated with poorer motor performances in the elderly, but the role of gray matter atrophy remains largely unknown. We investigated the cross-sectional relation between brain regional gray matter volumes and walking speed over 6 m in the 3C-Dijon study, a large population-based study of community-dwelling persons aged 65 years and over (N=1623). Regional gray matter volumes were obtained using an automated anatomical labeling parcellation method. Multivariable analyses were performed using a semi-Bayes approach. After adjustment for potential confounders, persons who walked slower had a smaller volume of basal ganglia (regression coefficient [beta] = 0.054. standard error [SE] = 0.028, p = 0.05). In more detailed analyses, the volume of the caudate nucleus had a preponderant role on this association (beta = 0.049, SE = 0.019, p = 0.009), and walking speed decreased progressively with the volume of the caudate nucleus (p for linear trend <0.001). These results underline the role of gray matter subcortical structures, in particular of the caudate nucleus, in the age-related decline of motor performances among community-dwelling elderly subjects. (c) 2012 Elsevier Inc. All rights reserved.
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