Journal
NEUROIMAGE
Volume 62, Issue 4, Pages 2232-2243Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2012.03.035
Keywords
Spontaneous brain activity; Non-invasive brain stimulation; Neuro-navigation; Anticorrelation; fMRI
Funding
- NIH [R25NS065743]
- Beth Israel Deaconess Medical Center
- Harvard-MIT Division of Health Sciences and Technology
- National Center for Research Resources: Harvard Clinical and Translational Science Center [UL1 RR025758]
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Both resting state functional magnetic resonance imaging (fcMRI) and transcranial magnetic stimulation (TMS) are increasingly popular techniques that can be used to non-invasively measure brain connectivity in human subjects. TMS shows additional promise as a method to manipulate brain connectivity. In this review we discuss how these two complimentary tools can be combined to optimally study brain connectivity and manipulate distributed brain networks. Important clinical applications include using resting state fcMRI to guide target selection for TMS and using TMS to modulate pathological network interactions identified with resting state fcMRI. The combination of TMS and resting state fcMRI has the potential to accelerate the translation of both techniques into the clinical realm and promises a new approach to the diagnosis and treatment of neurological and psychiatric diseases that demonstrate network pathology. (C) 2012 Elsevier Inc. All rights reserved.
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