Journal
NEUROIMAGE
Volume 60, Issue 3, Pages 1880-1889Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2012.01.062
Keywords
Disease progression; MRI; Alzheimer's disease; Huntington's disease
Funding
- CHDI Foundation, Inc.
- EPSRC (UK) [EP/D506468/01, EP/E007748]
- TSB [M1638A]
- CBRC [168]
- Alzheimer's Society
- MRC (UK)
- National Institute for Health Research through North Thames Dementias and Neurodegenerative Research Network, DeNDRoN
- Department of Health's NIHR Biomedical Research Centres
- Alzheimer's Research UK
- Alzheimers Research UK [ART-EG2010B-1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/G007748/1] Funding Source: researchfish
- Medical Research Council [G0601846] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10123] Funding Source: researchfish
- EPSRC [EP/G007748/1] Funding Source: UKRI
- MRC [G0601846] Funding Source: UKRI
Ask authors/readers for more resources
Understanding the progression of neurological diseases is vital for accurate and early diagnosis and treatment planning. We introduce a new characterization of disease progression, which describes the disease as a series of events, each comprising a significant change in patient state. We provide novel algorithms to learn the event ordering from heterogeneous measurements over a whole patient cohort and demonstrate using combined imaging and clinical data from familial Alzheimer's and Huntington's disease cohorts. Results provide new detail in the progression pattern of these diseases, while confirming known features, and give unique insight into the variability of progression over the cohort. The key advantage of the new model and algorithms over previous progression models is that they do not require a priori division of the patients into clinical stages. The model and its formulation extend naturally to a wide range of other diseases and developmental processes and accommodate cross-sectional and longitudinal input data. (C) 2012 Elsevier Inc. All rights reserved.
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