Journal
NEUROIMAGE
Volume 63, Issue 1, Pages 540-552Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2012.06.076
Keywords
Proton density; Spin density; Water content; Receiver sensitivity profile; T1
Funding
- Bundesministerium fur Bildung und Forschung (Brain Imaging Center Frankfurt) [DLR 01GO0203]
- Deutsche Forschungsgemeinschaft [ZA 233/1-1]
- LOEWE-Program Neuronal Coordination Forschungsschwerpunkt Frankfurt (NeFF)
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Most methods for mapping proton densities (PD) in brain tissue are based on measuring all parameters influencing the signal intensity with subsequent elimination of any weighting not related to PD. This requires knowledge of the receiver coil sensitivity profile (RP), the measurement of which can be problematic. Recently, a method for compensating the influence of RP non-uniformities on PD data at a field strength of 3 T was proposed, based on bias field correction of spoiled gradient echo image data to remove the low spatial frequency bias imposed by RP variations from uncorrected PD maps. The purpose of the current study was to present and test an independent method, based on the well-known linear relationship between the longitudinal relaxation rate R1 and 1/PD in brain tissue. For healthy subjects, RP maps obtained with this method and the resulting PD maps are very similar to maps based on bias field correction, and quantitative PD values acquired with the new independent method are in very good agreement with literature values. Furthermore, both methods for PD mapping are compared in the presence of several pathologies (multiple sclerosis, stroke, meningioma, recurrent glioblastoma). (C) 2012 Elsevier Inc. All rights reserved.
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