Journal
NEUROIMAGE
Volume 60, Issue 1, Pages 83-94Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2011.11.082
Keywords
Diffusion weighted imaging; Sub-thalamic nucleus; Segmentation; Connectivity; Hemiballismus
Funding
- Wellcome Trust [075696/Z/04/Z, 091593/Z/10/Z]
- Department of Health NIHR Biomedical Research Centres
- Parkinson's Appeal
- Edmond J. Safra Philanthropic Foundation
- Monument Trust
- National Institute for Health Research [CL-2012-16-501] Funding Source: researchfish
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The subthalamic nucleus (STN) is a small, glutamatergic nucleus situated in the diencephalon. A critical component of normal motor function, it has become a key target for deep brain stimulation in the treatment of Parkinson's disease. Animal studies have demonstrated the existence of three functional sub-zones but these have never been shown conclusively in humans. In this work, a data driven method with diffusion weighted imaging demonstrated that three distinct clusters exist within the human STN based on brain connectivity profiles. The STN was successfully sub-parcellated into these regions, demonstrating good correspondence with that described in the animal literature. The local connectivity of each sub-region supported the hypothesis of bilateral limbic, associative and motor regions occupying the anterior, mid and posterior portions of the nucleus respectively. This study is the first to achieve in-vivo, non-invasive anatomical parcellation of the human STN into three anatomical zones within normal diagnostic scan times, which has important future implications for deep brain stimulation surgery. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.
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