Journal
NEUROIMAGE
Volume 58, Issue 3, Pages 838-848Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2011.06.068
Keywords
FMRI; IMaGES; Group analysis; Effective connectivity; Causal modeling; Directionality
Funding
- James S. McDonnell Foundation
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Smith et al. report a large study of the accuracy of 38 search procedures for recovering effective connections in simulations of DCM models under 28 different conditions. Their results are disappointing: no method reliably finds and directs connections without large false negatives, large false positives, or both. Using multiple subject inputs, we apply a previously published search algorithm, IMaGES, and novel orientation algorithms, LOFS, in tandem to all of the simulations of DCM models described by Smith et al. (2011). We find that the procedures accurately identify effective connections in almost all of the conditions that Smith et al. simulated and, in most conditions, direct causal connections with precision greater than 90% and recall greater than 80%. (C) 2011 Elsevier Inc. All rights reserved.
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