Journal
NEUROIMAGE
Volume 57, Issue 3, Pages 1015-1021Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2011.05.010
Keywords
fMRI; Ultra high field; Patient; Motor; Sensitivity
Funding
- Austrian Science Fund [P18057-B13]
- Vienna Spots of Excellence Programme VIACLIC
- Austrian Science Fund (FWF) [P18057] Funding Source: Austrian Science Fund (FWF)
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Despite there being an increasing number of installations of ultra high field MR systems (>3 T) in clinical environments, no functional patient investigations have yet examined possible benefits for functional diagnostics. Here we performed presurgical localization of the primary motor hand area on 3 T and 7 T Siemens scanners with identical investigational procedures and comparable system specific sequence optimizations. Results from 17 patients showed significantly higher functional sensitivity of the 7 T system measured via percent signal change, mean t-values, number of suprathreshold voxels and contrast to noise ratio. On the other hand, 7 T data suffered from a significant increase of artifacts (ghosting, head motion). We conclude that ultra high field systems provide a clinically relevant increase of functional sensitivity for patient investigations. (C) 2011 Elsevier Inc. All rights reserved.
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