Left fusiform BOLD responses are inversely related to word-likeness in a one-back task

Although its precise functional contribution to reading remains unclear, there is broad consensus that an activity in the left mid-fusiform gyrus is highly sensitive to written words and word-like stimuli. In the current study, we take advantage of a particularity of the Chinese writing system in order to manipulate word-likeness parametrically, from real characters, to pseudo-characters that vary in whether they contain phonological and semantic cues, to artificial stimuli with varying surface similarity to real characters. In a one-back task, BOLD activity in the left mid-fusiform was inversely related to word-likeness, such that the least activity was observed in response to real characters, and the greatest to artificial stimuli that violate the orthotactic constraints of the writing system. One possible explanation for this surprising result is that the short-term memory demands of the one-back task put more pressure on the visual system when other sources of information cannot be used to aid in detecting repeated stimuli. For real characters and, to a lesser extent for pseudo-characters, information about meaning and pronunciation can contribute to performance, whereas artificial stimuli are entirely dependent on visual information. Consistent with this view, functional connectivity analyses revealed a strong positive relationship between left mid-fusiform and other visual areas, whereas areas typically involved in phonological and semantic processing for text were negatively correlated with this region. (C) 2011 Elsevier Inc. All rights reserved.