Journal
NEUROIMAGE
Volume 54, Issue -, Pages S176-S179Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2010.05.032
Keywords
Longitudinal relaxation time; Longitudinal relaxivity; Water proton; Contrast agents
Funding
- NIH [R01 CA135329-01]
- NATIONAL CANCER INSTITUTE [R01CA135329] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL070023] Funding Source: NIH RePORTER
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The longitudinal relaxivity on the protons of water of a Gd-chelate-albumin compound was measured at 7 T as a function of the macromolecular content of a cross-linked matrix. In agreement with previous works, the results demonstrate that the effect of gadolinium on water proton relaxivity is not constant, rising moderately with increase in the concentration of bovine serum albumin (BSA). About 35% variation in relaxivity was observed over a 0%-25% range of BSA concentrations (R = 3.893 + 0.0502 x BSA [%], SE-.0119 and 0.1740, t-4.215 and 22.383, p<0.014 and 0.001). (C) 2010 Elsevier Inc. All rights reserved.
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