Journal
NEUROIMAGE
Volume 56, Issue 3, Pages 1021-1026Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2011.02.035
Keywords
Cocaine; Addiction; Voxel-based morphometry; MRI; Striatum; Amygdala
Funding
- FEPAD (Fundacion para el Estudio, Prevencion y Asistencias a la Drogodependencia)
- National Plan of Drugs (Plan Nacional de Drogas)
- CONSOLIDER-INGENIO Program [CSD2007-00012]
Ask authors/readers for more resources
Long-term cocaine consumption is associated with brain structural and functional changes. While the animal literature on cocaine use and dependence has traditionally focused on the striatum, previous human studies using voxel-based morphometry have reported reduced volumes of gray matter in several brain areas, but not in the striatum. Brain magnetic resonance imaging was performed with 20 cocaine-dependent patients and 16 healthy age-, education- and intelligence-matched control men. The cocaine-dependent group had lower gray matter volumes in the striatum and right supramarginal gyrus compared to controls. Within the cocaine-dependent group, years of cocaine use were inversely associated with the volume of the bilateral middle frontal gyms, left superior frontal gyrus. parahippocampus, posterior cingulate. amygdala, insula. right middle temporal gyrus and cerebellum. These results show that cocaine dependence is associated with reduced gray matter volumes in the target structures of the dopaminergic system. These findings are the first to suggest reduced gray matter in the striatum by means of voxel-basecl morphometry in human users, thereby linking human results to animal models of addiction. In addition, the relationship between years of use and gray matter volumes in numerous brain regions are consistent with these volume reductions arising as a consequence of the cocaine use. (C) 2011 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available