Journal
NEUROIMAGE
Volume 57, Issue 2, Pages 403-415Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2011.04.054
Keywords
Thalamus; Probabilistic diffusion tensor imaging; Structural parcellation; Distribution of probability of connectivity; Thalamic subdivison
Funding
- National Institute for Health Research
- Medical Research Council [G0300117]
- European Union [FP7-ICT-2009-C 238292]
- MRC [G0300117, G1002276] Funding Source: UKRI
- Medical Research Council [G0300117, G1002276] Funding Source: researchfish
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Virtually all information that enters the cortex must first pass through the thalamus. This prominent role has made the human thalamus a target for detailed imaging studies. It has previously been shown that probabilistic tractography together with cortical parcellation allowed subdivision of the thalamus into its constituent substructures. A new method is presented that allows the subdivision of the thalamus according to its cortical projection targets based on the assumption that any cortical region receives input from the thalamus and calculates the probability of connectivity distribution functions based on probabilistic tractography. The feasibility of the method was tested in a data set of 43 healthy children aged between 8 and 13 years. A thalamic parcellation pattern similar to that previously found in adults and children below the age of 2 years was obtained. However, no evidence for an age related change in cortical parcellation volumes were found in line with previously reported studies of thalamic volumes during development. Lower standard deviations were found for the two smallest projections, the sensory and occipital projection using the new method. Furthermore it was found, through comparison with a published thalamic atlas, that the method allowed the localization of the center of the different thalamic projection areas within an accuracy of 2 mm. Crown Copyright (C) 2011 Published by Elsevier Inc. All rights reserved.
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