4.7 Article

Robust subdivision of the thalamus in children based on probability distribution functions calculated from probabilistic tractography

Journal

NEUROIMAGE
Volume 57, Issue 2, Pages 403-415

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2011.04.054

Keywords

Thalamus; Probabilistic diffusion tensor imaging; Structural parcellation; Distribution of probability of connectivity; Thalamic subdivison

Funding

  1. National Institute for Health Research
  2. Medical Research Council [G0300117]
  3. European Union [FP7-ICT-2009-C 238292]
  4. MRC [G0300117, G1002276] Funding Source: UKRI
  5. Medical Research Council [G0300117, G1002276] Funding Source: researchfish

Ask authors/readers for more resources

Virtually all information that enters the cortex must first pass through the thalamus. This prominent role has made the human thalamus a target for detailed imaging studies. It has previously been shown that probabilistic tractography together with cortical parcellation allowed subdivision of the thalamus into its constituent substructures. A new method is presented that allows the subdivision of the thalamus according to its cortical projection targets based on the assumption that any cortical region receives input from the thalamus and calculates the probability of connectivity distribution functions based on probabilistic tractography. The feasibility of the method was tested in a data set of 43 healthy children aged between 8 and 13 years. A thalamic parcellation pattern similar to that previously found in adults and children below the age of 2 years was obtained. However, no evidence for an age related change in cortical parcellation volumes were found in line with previously reported studies of thalamic volumes during development. Lower standard deviations were found for the two smallest projections, the sensory and occipital projection using the new method. Furthermore it was found, through comparison with a published thalamic atlas, that the method allowed the localization of the center of the different thalamic projection areas within an accuracy of 2 mm. Crown Copyright (C) 2011 Published by Elsevier Inc. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available