Journal
NEUROIMAGE
Volume 56, Issue 4, Pages 2249-2257Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2011.03.059
Keywords
Inhibitory control; Pre-SMA; tDCS; Stop signal task
Funding
- National Science Council, Taiwan [99-2410-H-008-022-MY3, 99-2911-I-008-025, 97-2511-S-008-005-MY3, 98-2410-H-008-010-MY3, 98-2517-S-004-001-MY3, 97-2511-S-008-008-MY5, 98-2918-I-008-011]
- UK Medical Research Council
- Royal Society
- Fulbright scholarship, Taiwan-USA
- MRC [G0700929] Funding Source: UKRI
- Medical Research Council [G0700929] Funding Source: researchfish
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The executive control of voluntary action involves not only choosing from a range of possible actions but also the inhibition of responses as circumstances demand. Recent studies have demonstrated that many clinical populations, such as people with attention-deficit hyperactivity disorder, exhibit difficulties in inhibitory control. One prefrontal area that has been particularly associated with inhibitory control is the pre-supplementary motor area (Pre-SMA). Here we applied non-invasive transcranial direct current stimulation (tDCS) over Pre-SMA to test its role in this behavior. tDCS allows for current to be applied in two directions to selectively excite or suppress the neural activity of Pre-SMA. Our results showed that anodal tDCS improved efficiency of inhibitory control. Conversely, cathodal tDCS showed a tendency towards impaired inhibitory control. To our knowledge, this is the first demonstration of non-invasive intervention tDCS altering subjects' inhibitory control. These results further our understanding of the neural bases of inhibitory control and suggest a possible therapeutic intervention method for clinical populations. (C) 2011 Elsevier Inc. All rights reserved.
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