Journal
NEUROIMAGE
Volume 49, Issue 3, Pages 1957-1964Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2009.08.040
Keywords
Functional MRI; fMRI; Ultra high-field; 7 T; High-resolution; Multivariate analysis; Decoding; Classification; Visual cortex; Striate cortex; V1; Cortical columns; Ocular dominance
Funding
- NCRR NIH HHS [P41 RR08079, P41 RR008079] Funding Source: Medline
- NIBIB NIH HHS [R01 EB000331, R01-EB000331] Funding Source: Medline
- NIMH NIH HHS [R01 MH070800, R01-MH070800] Funding Source: Medline
- NINDS NIH HHS [P30 NS057091] Funding Source: Medline
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Recent Studies have demonstrated that multivariate machine learning algorithm applied to human functional MRI data call decode information segregated in cortical columns, despite the voxel size being large relative to the width Of columns The mechanism by which low spatial resolution imaging decodes information represented in a fine-scale organization is nor clear. To investigate mechanisms underlying decoding signals we employed high-resolution gradient-echo BOLD functional MRI Of Visual area VI We show that in addition to the fine-scale ocular dominance columns, coarse-scale Structures extending over several millimeters also convey discriminative power for decoding the stimulated eye Discriminative power is conveyed by both macroscopic blood vessels and gray matter regions. We hypothesize that gray-matter regions which drain into specific vessels may preferentially contain ocular-dominance columns biased towards one eye, the bias of a specific region thereby causing a functionally selective ocular-dominance response in the associated vessel Our findings indicate that coarse-scale Structures and macroscopic blood vessels contribute to decoding of the stimulated eye based oil low-resolution multivariate data. (C) 2009 Elsevier Inc All rights reserved
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