Journal
NEUROIMAGE
Volume 47, Issue -, Pages T58-T65Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2009.02.004
Keywords
Correlation analysis; Diffusion tensor imaging; Fluid attenuated inversion recovery; White matter degeneration; White matter lesion
Funding
- NIA NIH HHS [P01 AG012435-139001, P01 AG012435, P01AG0124335] Funding Source: Medline
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Fluid attenuated inversion recovery (FLAIR) and diffusion tensor imaging (DTI) techniques have been widely used to evaluate white matter (WM) alterations associated with aging, dementia and cerebral vascular disease. The relationship between FLAIR detected WM lesions (WML) and DTI detected WM integrity changes, however, remains unclear. To investigate this association, voxelwise correlations between 4 Tesla DTI and FLAIR images from elderly subjects were performed by relating WML volume and intensity in FLAIR to fractional anisotropy (FA) and mean diffusivity (MID) in DTI. Significant DTI-FLAIR correlations were found in regions overlapping with the WML of moderate intensities in FLAIR. No significant correlations were detected in periventricular regions where the FLAIR intensities are particularly high. The findings are consistent with a transitional model for WM degeneration from normal WM to cerebrospinal fluid (CSF). The results show that the correlation between DTI and FLAIR disappears when the FLAIR intensity of WML reaches its maximum at a certain lesion severity, and that the Correlations may remerge with reversed signs when the lesion severity is further increased. These results suggest that the different stages of WM degeneration in elderly Subjects can be better characterized by regional DTI-FLAIR correlations than single modality alone. (C) 2009 Elsevier Inc. All rights reserved.
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