Journal
NEUROIMAGE
Volume 39, Issue 1, Pages 231-237Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2007.08.030
Keywords
magnetic resonance elastography; shear stiffness; elasticity; mechanical properties; tissue characterization; brain
Funding
- NCI NIH HHS [R01 CA075552-03, R01 CA075552-05, R01 CA075552-04] Funding Source: Medline
- NIBIB NIH HHS [R01 EB001981, R01 EB001981-07, R01 EB001981-06, R01 EB001981-08, R01 EB001981-10, R01 EB001981-09] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA075552] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB001981] Funding Source: NIH RePORTER
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The purpose of this study was to obtain normative data using magnetic resonance elastography (MRE) (a) to obtain estimates of the shear modulus of human cerebral tissue in vivo and (b) to assess a possible age dependence of the shear modulus of cerebral tissue in healthy adult volunteers. MR elastography studies were performed on tissue-simulating gelatin phantoms and 25 healthy adult volunteers. The data were analyzed using spatiotemporal filters and a local frequency estimating algorithm. Statistical analysis was performed using a paired t-test. The mean shear stiffness of cerebral white matter was 13.6 kPa (95% Cl 12.3 to 14.8 kPa); while that of gray matter was lower at 5.22 kPa (95% Cl 4.76 to 5.66 kPa). The difference was statistically significant (p < 0.0001). (C) 2007 Published by Elsevier Inc.
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