Journal
NEUROIMAGE
Volume 39, Issue 1, Pages 261-268Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2007.07.061
Keywords
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Funding
- NIBIB NIH HHS [R01 EB004346-03, R01 EB004346, R01 EB004346-01A1] Funding Source: Medline
- NIDA NIH HHS [R01 DA15410, R01 DA015410] Funding Source: Medline
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB004346] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA015410] Funding Source: NIH RePORTER
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When planning most scientific studies, one of the first steps is to carry out a power analysis to define a design and sample size that will result in a well-powered study. There are limited resources for calculating power for group fMRI studies due to the complexity of the model. Previous approaches for group fMRI power calculation simplify the study design and/or the variance structure in order to make the calculation possible. These approaches limit the designs that can be studied and may result in inaccurate power calculations. We introduce a flexible power calculation model that makes fewer simplifying assumptions, leading to a more accurate power analysis that can be used on a wide variety of study designs. Our power calculation model can be used to obtain region of interest (ROI) summaries of the mean parameters and variance parameters, which can be use to increase understanding of the data as well as calculate power for a future study. Our example illustrates that minimizing cost to achieve 80% power is not as simple as finding the smallest sample size capable of achieving 80% power, since smaller sample sizes require each subject to be scanned longer. (C) 2007 Elsevier Inc. All rights reserved.
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