Journal
NEUROIMAGE
Volume 39, Issue 3, Pages 1429-1443Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2007.09.054
Keywords
auditory feedback control; speech production; neural modeling; functional magnetic resonance imaging; structural equation modeling; effective connectivity
Funding
- NCRR NIH HHS [P41RR14075, P41 RR014075] Funding Source: Medline
- NIDCD NIH HHS [R01 DC02852, R01 DC002852] Funding Source: Medline
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The neural substrates underlying auditory feedback control of speech were investigated using a combination of functional magnetic resonance imaging (fMRI) and computational modeling. Neural responses were measured while subjects spoke monosyllabic words under two conditions: (i) normal auditory feedback of their speech and (ii) auditory feedback in which the first formant frequency of their speech was unexpectedly shifted in real time. Acoustic measurements showed compensation to the shift within approximately 136 ms of onset. Neuroimaging revealed increased activity in bilateral superior temporal cortex during shifted feedback, indicative of neurons coding mismatches between expected and actual auditory signals, as well as right prefrontal and Rolandic cortical activity. Structural equation modeling revealed increased influence of bilateral auditory cortical areas on right frontal areas during shifted speech, indicating that projections from auditory error cells in posterior superior temporal cortex to motor correction cells in right frontal cortex mediate auditory feedback control of speech. (c) 2007 Elsevier Inc. All rights reserved.
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