Journal
NEUROGASTROENTEROLOGY AND MOTILITY
Volume 26, Issue 6, Pages 841-850Publisher
WILEY
DOI: 10.1111/nmo.12340
Keywords
functional abdominal pain; inflammation; irritable bowel syndrome; microbiology
Funding
- Stockholm County Council
- Swedish Research Council
- Swedish Research Council Formas
- Swedish Heart and Lung Foundation
- Swedish Asthma and Allergy Association
- Swedish Foundation for Health Care Science and Allergy Research
- Karolinska Institutet [20110237]
- Foreningen Mjolkdroppen
- Kempe Carlgrenska Foundation
- Juhlin Foundation
- Karolinska Institutet Funds
- Stiftelsen Samariten
- Mjolkdroppen Foundation
- Jane and Dan Olsson Foundation
- Majblomman Foundation
- Stockholm county
- Orebro University Hospital
- Swedish Society of Medicine
- Swedish Research Council - Medicine [522-2A09-195]
- Sven Jerring Foundation
- Orebro Society of Medicine
- Clas Groschinsky Foundation
- Uppsala-Orebro Regional Research Council
- Swedish Celiac Society
- Swedish Research Council (SIMSAM grant) [80748301]
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Background The etiology of recurrent abdominal pain of functional origin (AP) is largely unknown. Antibiotic treatment influences the intestinal microbiota, and a few studies have indicated an increased risk of AP in adults after antibiotic treatment. Corresponding data in children are lacking. The aim of this study was to explore the association between antibiotic treatment during childhood and AP at 12years. Methods Two thousand seven hundred and thirty-two children from a Swedish, population-based birth cohort. Parents reported antibiotic use for the children between birth and 2years. Antibiotic use between 9 and 12years was collected from the Swedish Prescribed Drug Register. The children answered questionnaires regarding AP at age 12. We used logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for AP at 12years as a function of antibiotic use. Key Results Antibiotic treatment between 9 and 12years was not associated with AP at 12. Children who had received 3 courses, or broad-spectrum antibiotics between 9 and 12years had an increased risk of AP at 12, but these associations failed to reach statistical significance. Antibiotic treatment during both the first and the second year of life increased the risk of AP in girls at 12 (OR 1.65; 95% CI: 1.09-2.49), but not in boys or the whole cohort. Conclusions & Inferences Antibiotic treatment does not seem to be a major risk factor for AP at 12years. However, we cannot exclude that repeated courses, especially to infant girls, or use of broad-spectrum antibiotics between 9 and 12years may be associated with an increased risk of AP.
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